ASIT biotech is a clinical-stage company focused on developing therapies for allergies. It uses its proprietary ASIT+ technology platform to develop products containing highly purified allergen fragments in an adjuvant-free formulation, selected to be safe while maintaining the capacity to stimulate the immune system.
ASIT biotech’s ASIT+ short-course allergy immunotherapy (AIT) platform has generated a Phase III drug for the prevention of grass pollen allergy. Its earlier-stage programmes in house dust mite (hdm-ASIT+) and peanut allergies (pnt-ASIT+) will be developed via partnering. Unlike most other AITs (subcutaneous or sublingual), ASIT’s products only require four injections before the allergy season. The second Phase III study for gp-ASIT+ is underway and results are expected after the pollen season of 2019. We expect ASIT biotech to self-market gp-ASIT+ in Europe and out-license all other rights ex-Europe. The recently announced private placement of convertible bonds that fully funds ASIT’s clinical programmes until Q320 was completed in July.
Although grass pollen and house dust mite allergies are not life threatening in most cases, they result in a significant symptom burden for affected patients. With a safe and effective short-course pre-seasonal regimen, ASIT could expect some usage in patients accepting immunotherapy and the 50% of patients who refuse the existing almost year-round immunotherapy.