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Sparks commentary - OSE Immunotherapeutics

Healthcare

Sparks - OSE Immunotherapeutics

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OSE-Immunotherapeutics_resized
OSE Immunotherapeutics (PAR: OSE) on-track with registrational Tedopi trial
Published by Arron Aatkar, PhD

OSE Immunotherapeutics has received a positive recommendation from the independent data monitoring committee (IDMC) to continue the ARTEMIA programme without any modifications. This is the registrational Phase III trial evaluating OSE’s lead cancer vaccine, Tedopi, in non-small cell lung cancer (NSCLC). A second IDMC review is expected in Q126, and management then anticipates completing patient recruitment by end-2026, before a primary endpoint readout in Q128.

ARTEMIA (which commenced in September 2024) is investigating Tedopi as a potential second-line monotherapy for NSCLC, after the use of immune checkpoint inhibitors as first-line treatments. The trial has been designed to randomise participants (expected n=363) 2:1 to receive either Tedopi or docetaxel (standard of care in the second-line setting).

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