VolitionRx — Gaining more evidence

VolitionRx (NYSE: VNRX)

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Research: Healthcare

VolitionRx — Gaining more evidence

In May 2017, VolitionRx presented the final data from its 8,000-person clinical validation study of the Nu.Q™ Colorectal Cancer Screening Triage Test. Patients screened with this product would have required 24.5% fewer colonoscopies. The first potential market will be Denmark with feedback expected in about September 2017.

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Healthcare

VolitionRx

Gaining more evidence

Earnings update

Pharma & biotech

16 May 2017

Price

US$3.55

Market cap

US$94m

Net cash ($m) at end Q117

17.7

Shares in issue

26.4m

Free float

73%

Code

VNRX

Primary exchange

NYSE MKT

Secondary exchange

N/A

Share price performance

%

1m

3m

12m

Abs

(10.6)

(20.2)

3.8

Rel (local)

(13.3)

(22.0)

(11.6)

52-week high/low

US$5.6

US$3.1

Business description

VolitionRx is a diagnostics company focused on developing blood-based cancer diagnostics using its proprietary Nu.Q™ technology. Its lead program is in colorectal cancer, which recently received a CE mark, allowing for commercialization in Europe.

Next events

Danish CRC screening steering committee meeting

September 2017

Analysts

Maxim Jacobs

+1 646 653 7027

Nathaniel Calloway

+1 646 653 7036

VolitionRx is a research client of Edison Investment Research Limited

In May 2017, VolitionRx presented the final data from its 8,000-person clinical validation study of the Nu.Q™ Colorectal Cancer Screening Triage Test. Patients screened with this product would have required 24.5% fewer colonoscopies. The first potential market will be Denmark with feedback expected in about September 2017.

Year
end

Revenue ($m)

PBT*
($m)

EPS*
($)

DPS
($)

P/E
(x)

Yield
(%)

12/15

0.0

(9.7)

(0.54)

0.0

N/A

N/A

12/16

0.0

(12.3)

(0.53)

0.0

N/A

N/A

12/17e

0.7

(14.1)

(0.53)

0.0

N/A

N/A

12/18e

2.5

(18.7)

(0.68)

0.0

N/A

N/A

Note: *PBT and EPS are normalised, excluding amortization of acquired intangibles, exceptional items and share-based payments.

Triage test: Successful 8,000-person clinical trial

VolitionRx presented data from the validation portion of the Nu.Q™ Colorectal Cancer Screening Triage Test clinical trial. This portion of the trial was prospective and examined 4,076 patients with a positive fecal immunochemical test (FIT) result. It found that it could eliminate 22% of these FIT-positive patients from needing a colonoscopy while identifying 95% of colorectal cancer (CRC) cases. When combined with the patients from previous portions, the total result would be a 24.5% reduction in colonoscopies, which is remarkably close to the 25% the test was designed for.

US trial being designed: 10,000 undiagnosed

The company announced on the Q117 conference call that it is in the design stages for a 10,000 undiagnosed person trial in the US for the frontline CRC screening test. This is approximately the same size of trial that was performed by Exact Sciences to support Cologuard. We believe the Nu.Q™ trial may have similar endpoints of 65% sensitivity for CRC and 85% specificity for advanced neoplasias.

Outlook: $2.5m to $3.0m burn per quarter

The company provided guidance on spending for 2017 of approximately $2.5m to $3.0m per quarter, which is indicative of the company’s continued cost control. Q117 spending was higher ($3.2m) due to $875,000 invested in a new Belgian R&D facility. We expect this facility to enable the continued development of the frontline CRC, lung cancer, and pancreatic cancer programs.

Valuation: Unchanged at $272m

Our valuation of VolitionRx remains unchanged at $272m, although it has decreased slightly on a per-share basis to $10.32 per basic share from $10.40 per basic share. We have increased the probability of success for the Nu.Q™ colorectal triage test to 50% (from 30%) following the data from the validation study. However, this was offset by a reduction in the value for the CRC frontline test due to delaying the launch of the product to 2018. VolitionRx ended Q117 with $17.7m in net cash, and we expect it to require $45m in additional cash to reach profitability in 2021.

Triage test validation data reported

As part of the clinical development of the Nu.Q™ Colorectal Cancer Screening Triage Test, VolitionRx has completed an 8,000-person prospective clinical trial of patients with a positive FIT result. These patients presented at Hvidovre Hospital in Copenhagen after being identified by the country’s CRC screening program and were followed up with colonoscopy. The trial was broken into three sections: a 2,000-person training set in which the parameters of the test were set, and 2,000- and 4,000-person validation sets. The company set a target of a 25% negative test rate (meaning a potential 25% reduction in colonoscopies), and the validation data can be considered a success if it can replicate these data. The company presented data from the final 4,000-person validation cohort and provided an overview of the full 8,000-person data set at the Digestive Disease Week conference in May 2017. It found that 22% of patients were negative for the Nu.Q™ test in the new validation set, and 24.5% overall for the full 8,000-person trial. This is exceptionally close to the 25% target and based on this we can consider that the tests perform as expected in a real-world CRC-screening setting.

Exhibit 1: Nu.Q™ Colorectal Cancer Screening Triage Test 4,000-person validation set

Result by colonoscopy

n

Nu.Q™

Pos

Neg

% Neg

No disease

1,838

1,292

546

30%

Adenoma

2,039

1,683

356

17%

Low risk

838

652

186

22%

Medium risk

698

579

119

17%

High risk

503

452

51

10%

CRC

199

191

8

4%

1

99

94

5

5%

2

41

40

1

2%

3

43

41

2

5%

4

13

13

0

0%

unknown

3

3

0

0%

Total

4,076

3,166

910

22%

Source: VolitionRx

A key comparator for this study was with a “high threshold” FIT. All patients on the study were FIT positive at the standard lower threshold, and a potentially reasonable way of reducing colonoscopies is raising this threshold. The high threshold FIT reduced the number of positive patients by 36%, but at the cost of missing 9% of patients with cancer. By comparison, the Nu.Q™ triage test missed approximately half as many (4% in the 4,000-person set, 5% in the full trial) of the real cancer patients compared to high threshold FIT. Similarly, the Nu.Q™ test was much better at identifying patients with high-risk adenoma (90% sensitivity in the 4,000 person set, 88% in the full trial) compared to high threshold FIT (75%).

These results set up the triage test as an attractive prospect for national cancer screening programs. The company performed the trial in part to validate the test’s utility to the Danish government, which will be the first region targeted. The company previously met with the steering group in charge of the Danish CRC screening program in September 2016, and the earliest we expect feedback on the potential adoption of Nu.Q™ in the country will be at the group’s next meeting in September 2017.

US clinical trial in the works

The company announced on the Q117 earnings call that it is in the design stages for a 10,000-person trial in the US for the frontline CRC screening test. The company has formed a US subsidiary (Volition America, Inc.) to perform the trial. This is approximately the same size as a clinical trial used by Exact Sciences to support approval of Cologuard. The company has not provided any more detail on the trial’s design, or provided a timeline for its initiation, although we expect details to be forthcoming. Both the Cologuard pivotal trial and the pivotal trial for Epi proColon from Epigenomics had the same two primary endpoints: 65% or higher sensitivity for CRC and an 85% or higher specificity for advanced neoplasias (meaning that 85% of patients without CRC or high-grade adenomas were correctly identified). We believe a similar target may be required for the VolitionRx study. Previous Nu.Q™ panels have produced CRC sensitivity ratings in the range of 81-91%, although these studies were largely retrospective in nature. Additionally we do not have good data on specificity of the test for advanced neoplasias, although the sensitivity for adenomas of approximately 75% has historically been one of the highest among non-invasive tests. The company will have some leeway in determining the correct test parameters to optimize for these two clinical endpoints, as well as additional data gained over years of testing different Nu.Q™ panels that can be optimized. We look forward to hearing more about the clinical trial design in the coming months.

Valuation

Our valuation of VolitionRx remains unchanged at $272m, although it has decreased slightly on a per share basis to $10.32 per basic share from $10.40 per basic share due to an increase in total shares (26.4m from 26.1m). Some of the underlying assumptions for our valuation have changed, although these have coincidentally balanced to no net effect. We have delayed the first sales of the front-line CRC screening test to 2018 (from late 2017), which has decreased its rNPV to $170m from $180m. Additionally we have adjusted for lower net cash ($17.7m from $21.2m) at Q117. These effects were offset by an increase in the probability of success for the triage test (to 50% from 30%) based on the validation trial. We expect to update our valuation in the future with new clinical results as well as any regulatory decisions regarding the triage test rollout.

Exhibit 2: VolitionRx valuation table

Product

Main indication

Status

Prob. of commercial success

Launch year

Peak sales ($m)

Patent protection

Economics

rNPV ($m)

Nu.Q™

Colorectal

Development

30%

2018

$404

2034

56% peak margin

$170

 

Colorectal triage

Pre-commercialization

50%

2017

$42

2034

50% peak margin

$29

 

Lung

Development

30%

2018

$145

2034

61% peak margin

$44

Pancreatic

Development

30%

2018

$37

2034

58% peak margin

$11

Total

 

 

 

 

 

 

 

$254

Cash and cash equivalents (Q117) ($m)

$17.7

Total firm value ($m)

$272

Total basic shares (m)

26.4

Value per basic share ($)

$10.32

Warrants and options (3/2017, m)

2.1

Weighted average exercise price ($)

$2.40

Cash on exercise ($m)

$5.1

Total firm value ($m)

$277

Non-warrant options (3/2017, m)

3.1

Total number of shares (m)

31.6

Diluted value per share ($)

$8.76

Source: VolitionRx reports, Edison Investment Research

Financials

The company ended Q117 with $17.7m in net cash, and had cash outflows of $3.2m for the quarter, which included $875,000 spent on building the new research facility in Belgium. The company guided to a burn rate of $2.5m to $3.0m per quarter for the rest of the year. We have pushed back our launch timing for the front-line CRC test slightly to 2018, which enables this burn rate. We currently model a small number of sales of the Nu.Q™ Colorectal Cancer Screening Triage Test at the end of 2017 for the Danish screening program totaling $693,000. We expect that the company will need $45m in additional cash to reach profitability in 2021, which we currently include as illustrative debt ($15m in each of 2017, 2018, and 2019).

Exhibit 3: Financial summary

$000s

2012

2013

2014

2015

2016

2017e

2018e

Year end 31 December

US GAAP

US GAAP

US GAAP

US GAAP

US GAAP

US GAAP

US GAAP

PROFIT & LOSS

Revenue

 

 

55

0

15

0

0

693

2,483

Cost of Sales

0

0

0

0

0

(139)

(388)

Gross Profit

55

0

15

0

0

554

2,095

Research & Development

(2,843)

(2,504)

(4,044)

(6,102)

(6,838)

(7,521)

(8,273)

Sales, General & Administrative

(1,295)

(2,072)

(1,908)

(3,904)

(5,429)

(7,131)

(11,431)

EBITDA

 

 

(4,083)

(4,576)

(5,937)

(10,006)

(12,267)

(14,098)

(17,609)

Operating Profit (before GW and except.)

(4,083)

(4,576)

(5,937)

(10,006)

(12,267)

(14,098)

(17,609)

Intangible Amortization

0

0

0

0

0

0

0

Other

0

0

0

0

0

0

0

Exceptionals

0

0

0

0

0

0

0

Operating Profit

(4,083)

(4,576)

(5,937)

(10,006)

(12,267)

(14,098)

(17,609)

Net Interest

0

0

0

0

0

0

(1,136)

Other

(39)

840

(2,320)

471

252

32

0

Profit Before Tax (norm)

 

 

(4,083)

(4,576)

(8,358)

(9,666)

(12,267)

(14,098)

(18,745)

Profit Before Tax (FRS 3)

 

 

(4,122)

(3,736)

(8,258)

(9,535)

(12,014)

(14,067)

(18,745)

Tax

0

0

(0)

5

0

0

0

Deferred tax

0

0

(0)

(0)

(0)

(0)

(0)

Profit After Tax (norm)

(4,083)

(4,576)

(8,358)

(9,661)

(12,267)

(14,098)

(18,745)

Profit After Tax (FRS 3)

(4,122)

(3,736)

(8,258)

(9,530)

(12,014)

(14,067)

(18,745)

Average Number of Shares Outstanding (m)

9.4

10.8

13.5

17.7

23.0

26.7

27.7

EPS - normalised (c)

 

 

(43.62)

(42.24)

(62.08)

(54.49)

(53.22)

(52.90)

(67.63)

EPS - FRS 3 ($)

 

 

(0.44)

(0.34)

(0.61)

(0.54)

(0.52)

(0.53)

(0.68)

Dividend per share ($)

0.0

0.0

0.0

0.0

0.0

0.0

0.0

BALANCE SHEET

Fixed Assets

 

 

1,522

1,065

1,097

1,489

2,721

3,129

2,544

Intangible Assets

1,430

1,002

809

705

602

589

589

Tangible Assets

91

63

289

784

2,119

2,540

1,955

Other

0

0

(0)

(0)

(0)

(0)

(0)

Current Assets

 

 

416

941

2,192

6,070

21,846

25,213

25,098

Stocks

0

0

0

0

0

7

19

Debtors

0

0

0

0

0

123

442

Cash

376

889

2,139

5,916

21,679

24,914

24,467

Other

39

53

53

154

167

169

169

Current Liabilities

 

 

(695)

(957)

(2,713)

(1,120)

(2,033)

(2,417)

(3,126)

Creditors

(695)

(957)

(2,713)

(1,120)

(2,003)

(2,350)

(3,059)

Short term borrowings

0

0

0

0

(31)

(67)

(67)

Long Term Liabilities

 

 

(635)

(433)

(352)

(548)

(1,524)

(16,770)

(31,770)

Long term borrowings

0

0

0

0

(432)

(15,692)

(30,692)

Other long term liabilities

(635)

(433)

(352)

(548)

(1,092)

(1,079)

(1,079)

Net Assets

 

 

607

617

224

5,891

21,009

9,154

(7,254)

CASH FLOW

Operating Cash Flow

 

 

(2,315)

(3,084)

(4,141)

(8,766)

(9,056)

(11,229)

(15,421)

Net Interest

0

0

0

0

0

0

0

Tax

0

0

0

0

0

0

0

Capex

(91)

(1)

(303)

(352)

(415)

(875)

(25)

Acquisitions/disposals

0

0

0

0

0

0

0

Financing

2,576

2,828

5,627

12,498

25,302

43

0

Dividends

0

0

0

0

0

0

0

Other

0

0

0

0

(553)

(30)

0

Net Cash Flow

171

(257)

1,183

3,379

15,279

(12,091)

(15,446)

Opening net debt/(cash)

 

 

(348)

(376)

(889)

(2,139)

(5,916)

(21,216)

(9,156)

HP finance leases initiated

0

0

0

0

0

0

0

Exchange rate movements

(40)

4

(44)

13

146

(38)

0

Other

(103)

765

111

385

(125)

68

0

Closing net debt/(cash)

 

 

(376)

(889)

(2,139)

(5,916)

(21,216)

(9,156)

6,291

Source: VolitionRx reports, Edison Investment Research

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world-renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisers and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison and is not regulated by the Australian Securities and Investment Commission. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

DISCLAIMER
Copyright 2017 Edison Investment Research Limited. All rights reserved. This report has been commissioned by VolitionRx and prepared and issued by Edison for publication globally. All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report. Opinions contained in this report represent those of the research department of Edison at the time of publication. The securities described in the Investment Research may not be eligible for sale in all jurisdictions or to certain categories of investors. This research is issued in Australia by Edison Aus and any access to it, is intended only for "wholesale clients" within the meaning of the Australian Corporations Act. The Investment Research is distributed in the United States by Edison US to major US institutional investors only. Edison US is registered as an investment adviser with the Securities and Exchange Commission. Edison US relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. As such, Edison does not offer or provide personalised advice. We publish information about companies in which we believe our readers may be interested and this information reflects our sincere opinions. The information that we provide or that is derived from our website is not intended to be, and should not be construed in any manner whatsoever as, personalised advice. Also, our website and the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. This document is provided for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.
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London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

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10167, New York

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NSW 2000, Australia

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world-renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisers and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison and is not regulated by the Australian Securities and Investment Commission. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

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Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

245 Park Avenue, 39th Floor

10167, New York

US

Sydney +61 (0)2 8249 8342

Level 12, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

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