Associated equity: Sareum Holdings
Sareum is a UK-based drug development company, specialising in small molecule kinase inhibitors. Its flagship programmes are its pre-clinical TYK2/JAK1 inhibitors, SDC-1801 for autoimmune diseases and SDC-1802 for cancer. SDC-1801 is undergoing advanced dose finding and toxicology studies with a target to file a CTA in mid-2021. Other programmes include the CHK1 inhibitor SRA737 (Sareum holds a 27.5% economic interest), previously out licensed to Sierra Oncology and the de-prioritised FLT3+Aurora kinase.
Sareum Holdings — 5 videos in collection
In this interview, Dr John Reader, co-founder and CSO of Sareum, discusses the publication of the Phase I data for lead candidate SDC-1801 in the British Journal of Clinical Pharmacology and explains why the results strengthen confidence in the programme as it advances towards Phase II. He highlights the drug’s favourable safety profile, once-daily dosing potential and evidence of selective TYK2/JAK1 inhibition, while outlining its potential advantages over competing dual TYK2/JAK1 inhibitor, brepocitinib. John also provides an update on Phase II preparations, including ongoing toxicology studies and formulation optimisation, before discussing the broad commercial opportunity for SDC-1801 across autoimmune diseases, Sareum’s partnering strategy and the key catalysts investors should watch over the next 12–18 months.