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Oryzon Genomics has announced the first patient dosing in its Phase I trial, sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health. This study (NCT06514261) is assessing Oryzon’s potent and selective LSD1 inhibitor, iadademstat, in combination with venetoclax and azacitidine (standard of care) in newly diagnosed acute myeloid leukaemia (AML) patients. The trial aims to enrol 45 patients and is being conducted under a Cooperative Research and Development Agreement that Oryzon has in place with the NCI.
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