OpGen — FIND collaboration advances to development

OpGen (NASDAQ: OPGN)

Last close As at 15/06/2024

USD0.49

0.05 (11.62%)

Market capitalisation

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Research: Healthcare

OpGen — FIND collaboration advances to development

OpGen has announced that Curetis (its German subsidiary) has signed an extended R&D collaboration agreement with FIND following the successful completion of an extended feasibility study. The revised R&D agreement advances the collaboration from feasibility assessment to the initial phases of full in vitro diagnostic (IVD) product development, where the objective is to develop an antimicrobial resistance (AMR) IVD assay on an Unyvero A30 cartridge, along with analytical testing and software development. This development phase of the arrangement, with an anticipated 10-month duration, calls for a total $0.6m in additional payments to OpGen, split in the form of an upfront payment and two milestone payments. The progression of this collaboration takes OpGen a step closer toward commercialization of a molecular microbiology testing platform designed to address the needs of low-to-middle income countries (LMICs).

Nidhi Singh

Written by

Nidhi Singh

Analyst

Laboratory Opgen

Healthcare

OpGen

FIND collaboration advances to development

Collaboration update

Pharma and biotech

4 August 2023

Price

US$0.6

Market cap

US$4m

Pro-forma net cash ($m) at 31 March 2023 (including May 2023 equity raise)

0.2

Shares in issue

7.0m

Free float

92.5%

Code

OPGN

Primary exchange

Nasdaq

Secondary exchange

N/A

Share price performance

Business description

OpGen is primarily a lab diagnostic manufacturer focused on identifying and treating bacterial infections. With the acquisition of Curetis in H120, management has the technology necessary to detect pathogens and predict resistance. Through the dual platform offering of the AMR Gene Panel and Unyvero, the company can provide diagnostic results in hours instead of days under legacy technologies.

Analysts

Nidhi Singh

+44 (0)20 3077 5700

Arron Aatkar

+44 (0)20 3077 5700

OpGen is a research client of Edison Investment Research Limited

OpGen has announced that Curetis (its German subsidiary) has signed an extended R&D collaboration agreement with FIND following the successful completion of an extended feasibility study. The revised R&D agreement advances the collaboration from feasibility assessment to the initial phases of full in vitro diagnostic (IVD) product development, where the objective is to develop an antimicrobial resistance (AMR) IVD assay on an Unyvero A30 cartridge, along with analytical testing and software development. This development phase of the arrangement, with an anticipated 10-month duration, calls for a total $0.6m in additional payments to OpGen, split in the form of an upfront payment and two milestone payments. The progression of this collaboration takes OpGen a step closer toward commercialization of a molecular microbiology testing platform designed to address the needs of low-to-middle income countries (LMICs).

Year end

Revenue
($m)

EBITDA*

($m)

PBT*
($m)

EPS*
($)

P/revenue
(x)

Net debt/(cash)
($m)

12/21

4.3

(20.4)

(35.7)

(19.5)

0.84

(14.4)

12/22

2.6

(20.6)

(25.3)

(10.4)

1.38

4.4

12/23e

4.8

(17.9)

(20.8)

(3.4)

0.75

13.7

12/24e

7.1

(17.0)

(20.8)

(2.1)

0.51

34.5

Note: *Figures are normalized, excluding amortization of acquired intangibles, exceptional items and share-based payments. EPS adjusted for 1:20 share consolidation in January 23.

Under the expanded scope of the agreement, OpGen will collaborate with FIND to develop an AMR assay and an Unyvero A30 cartridge for AMR detection, designed to be suitable for the requirements of LMICs in terms of panel design, coverage of specified genetic variants of bacterial strains and its AMR markers, along with maintaining competitive cost profile and pricing to facilitate rapid testing in such countries. Additionally, the parties will work to develop a software plugin and conduct all analytical testing required to subsequently initiate clinical trials. While assay and software development work will start right away, the company expects to commence development work towards a first set of deliverables and milestones in Q423.

As a reminder, OpGen recently announced it has met all objectives agreed under the feasibility stage as part of the FIND collaboration, triggering a $0.2m milestone payment to OpGen. As per the expanded scope of the feasibility study for the Unyvero A30 RQ platform, OpGen provided three more deliverables: an antimicrobial stewardship module, a ‘data everywhere’ concept and next-generation sequencing strain analysis.

Further contract amendments or development phases may occur prior to the completion of an AMR product ready for clinical trials and regulatory submissions in relevant LMICs. While management expects the whole development process to targeted market launch in relevant LMICs might take two to three years (along with significant additional funding from FIND) to materialise, it includes an important opportunity to expand its Unyvero franchise into developing markets.

General disclaimer and copyright

This report has been commissioned by OpGen and prepared and issued by Edison, in consideration of a fee payable by OpGen. Edison Investment Research standard fees are £60,000 pa for the production and broad dissemination of a detailed note (Outlook) following by regular (typically quarterly) update notes. Fees are paid upfront in cash without recourse. Edison may seek additional fees for the provision of roadshows and related IR services for the client but does not get remunerated for any investment banking services. We never take payment in stock, options or warrants for any of our services.

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United Kingdom

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United Kingdom

General disclaimer and copyright

This report has been commissioned by OpGen and prepared and issued by Edison, in consideration of a fee payable by OpGen. Edison Investment Research standard fees are £60,000 pa for the production and broad dissemination of a detailed note (Outlook) following by regular (typically quarterly) update notes. Fees are paid upfront in cash without recourse. Edison may seek additional fees for the provision of roadshows and related IR services for the client but does not get remunerated for any investment banking services. We never take payment in stock, options or warrants for any of our services.

Accuracy of content: All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report and have not sought for this information to be independently verified. Opinions contained in this report represent those of the research department of Edison at the time of publication. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations.

Exclusion of Liability: To the fullest extent allowed by law, Edison shall not be liable for any direct, indirect or consequential losses, loss of profits, damages, costs or expenses incurred or suffered by you arising out or in connection with the access to, use of or reliance on any information contained on this note.

No personalised advice: The information that we provide should not be construed in any manner whatsoever as, personalised advice. Also, the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The securities described in the report may not be eligible for sale in all jurisdictions or to certain categories of investors.

Investment in securities mentioned: Edison has a restrictive policy relating to personal dealing and conflicts of interest. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report, subject to Edison's policies on personal dealing and conflicts of interest.

Copyright: Copyright 2023 Edison Investment Research Limited (Edison).

Australia

Edison Investment Research Pty Ltd (Edison AU) is the Australian subsidiary of Edison. Edison AU is a Corporate Authorised Representative (1252501) of Crown Wealth Group Pty Ltd who holds an Australian Financial Services Licence (Number: 494274). This research is issued in Australia by Edison AU and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. Any advice given by Edison AU is general advice only and does not take into account your personal circumstances, needs or objectives. You should, before acting on this advice, consider the appropriateness of the advice, having regard to your objectives, financial situation and needs. If our advice relates to the acquisition, or possible acquisition, of a particular financial product you should read any relevant Product Disclosure Statement or like instrument.

New Zealand

The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (i.e. without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision.

United Kingdom

This document is prepared and provided by Edison for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.

This Communication is being distributed in the United Kingdom and is directed only at (i) persons having professional experience in matters relating to investments, i.e. investment professionals within the meaning of Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended (the "FPO") (ii) high net-worth companies, unincorporated associations or other bodies within the meaning of Article 49 of the FPO and (iii) persons to whom it is otherwise lawful to distribute it. The investment or investment activity to which this document relates is available only to such persons. It is not intended that this document be distributed or passed on, directly or indirectly, to any other class of persons and in any event and under no circumstances should persons of any other description rely on or act upon the contents of this document.

This Communication is being supplied to you solely for your information and may not be reproduced by, further distributed to or published in whole or in part by, any other person.

United States

Edison relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. This report is a bona fide publication of general and regular circulation offering impersonal investment-related advice, not tailored to a specific investment portfolio or the needs of current and/or prospective subscribers. As such, Edison does not offer or provide personal advice and the research provided is for informational purposes only. No mention of a particular security in this report constitutes a recommendation to buy, sell or hold that or any security, or that any particular security, portfolio of securities, transaction or investment strategy is suitable for any specific person.

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

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