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Kazia Therapeutics

AU: KZA

Market CapAU$226m

Last Close AU$1.41

Kazia Therapeutics’ lead asset is paxalisib, a PI3K inhibitor licensed from Genentech that can cross the BBB. It is entering a pivotal study for GBM and is being investigated for other brain cancers such as breast cancer brain metastases.

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Investment summary

Kazia is developing the anti-cancer compound paxalisib (GDC-0084) for glioblastoma (GBM) multiforme. Paxalisib is a PI3K inhibitor, a well understood class with activity across a wide range of tumor types and multiple previously approved drugs. Paxalisib, unlike other drugs of this class, can cross the blood brain barrier (BBB), opening the potential to treat cancers of the brain. It is enrolling its first patients in the pivotal GBM AGILE study as of Q1 CY21.

Y/E Jun
Revenue (A$m)
EBITDA (A$m)
PBT (A$m)
EPS (fd) (c)
P/E (x)
P/CF (x)
2019A 1.6 (7.4) (7.4) (12.81) N/A N/A
2020A 1.1 (10.8) (10.8) (14.19) N/A N/A
2021E 16.8 1.5 1.5 1.22 146.3 N/A
2022E 1.6 (19.3) (19.3) (13.63) N/A N/A
Industry outlook

GBM is the most common primary cancer of the brain with 11,500 new cases reported in the United States per year. There are currently very limited treatment options for GBM and the disease has a very low survival rate. Paxalisib is currently being developed for use in the adjuvant setting after initial resection and radiation treatment.

Last updated on 24/11/2020
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Balance sheet
Forecast net cash (A$m) 32.1
Forecast gearing ratio (%) N/A
Key management
Iain Ross Chairman
James Garner CEO