Kazia Therapeutics’ lead asset is paxalisib, a PI3K inhibitor licensed from Genentech that can cross the BBB. It is entering a pivotal study for GBM and is being investigated for other brain cancers such as breast cancer brain metastases.
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Kazia is developing the anti-cancer compound paxalisib (GDC-0084) for glioblastoma (GBM) multiforme. Paxalisib is a PI3K inhibitor, a well understood class with activity across a wide range of tumour types and multiple previously approved drugs. Paxalisib, unlike other drugs of this class, can cross the blood brain barrier (BBB), opening the potential to treat cancers of the brain. The pivotal GBM AGILE study is currently enrolling patients. The second product candidate is EVT801, a novel small molecule inhibitor VEGFR3. A Phase I trial of EVT801 in solid tumours recently started enrolling patients.
Y/E Jun |
Revenue (A$m) |
EBITDA (A$m) |
PBT (A$m) |
EPS (fd) (c) |
P/E (x) |
P/CF (x) |
|---|---|---|---|---|---|---|
| 2020A | 1.1 | (10.8) | (10.8) | (14.19) | N/A | N/A |
| 2021A | 15.2 | (4.4) | (4.4) | (3.62) | N/A | N/A |
| 2022E | 2.2 | (16.3) | (16.3) | (11.53) | N/A | N/A |
| 2023E | 2.1 | (15.2) | (15.2) | (10.25) | N/A | N/A |
Industry outlook
GBM is the most common primary cancer of the brain with 11,500 new cases reported in the United States per year. There are very limited treatment options for GBM and there is a very low survival rate. Paxalisib is currently being developed for use in the adjuvant setting after initial resection and radiation treatment. EVT801 will target the multi billion angiogenesis cancer market.
Last updated on 18/01/2022Content on Kazia Therapeutics
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| Forecast net cash (A$m) | 11.6 |
| Forecast gearing ratio (%) | N/A |
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Key management |
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| Iain Ross | Chairman |
| James Garner | CEO |