BerGenBio is a clinical stage biopharmaceutical company developing innovative drugs for aggressive diseases, including immune-evasive, drug-resistant and metastatic cancers. It focuses on AXL inhibitors bemcentinib (small molecule) and tilvestamab (mAb).
BerGenBio (BGBIO) is a pioneer in AXL biology and the development of AXL inhibitors and has two clinical-stage assets: selective tyrosine kinase inhibitor bemcentinib and functional blocking monoclonal antibody tilvestamab. AXL expression is a negative prognostic marker in most cancers. Its upregulation drives aggressive disease including drug-resistant, immune-evasive and metastatic cancers, as well as fibrosis and viral infection. Selective AXL inhibition can prevent and reverse acquired drug resistance and stop immune suppression, potentially augmenting the efficacy of other cancer drug classes. BGBIO’s lead asset bemcentinib is in proof-of-concept studies in AML in combination with LDAC and in second-line NSCLC in combination with Keytruda. Discussions with regulators are ongoing regarding a pivotal study in relapsed AML, as well as in COVID-19 following top-line data from two Phase II trials in hospitalised COVID-19 patients.
Understanding the tumour microenvironment and why even with initial positive response to treatment, cancers often exhibit tumour proliferation, metastasis and treatment resistance is becoming an ever-more critical focus area. The role of AXL is becoming increasingly defined in tumorigenesis, propagation and treatment resistance.