Oncodesign Precision Medicine — Precision therapies for resistant diseases

Oncodesign Precision Medicine (ALOPM)

Last close As at 11/07/2025

EUR0.42

0.01 (2.44%)

Market capitalisation

EUR8m

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Research: Healthcare

Oncodesign Precision Medicine — Precision therapies for resistant diseases

Oncodesign Precision Medicine (OPM) is a clinical-stage biopharmaceutical company listed on Euronext Growth Paris. OPM is developing precision medicine therapies targeting treatment-resistant and metastatic cancers, as well as neurodegenerative diseases. Leveraging its proprietary platforms, OPM aims to deliver innovative, targeted treatments to address unmet medical needs. Lead asset OPM-101 is progressing into a Phase Ib/IIa trial (REVERT) for advanced melanoma. Additionally, OPM-201 for Parkinson’s disease (PD) has completed Phase I trials, showing favourable safety results. Strategic collaborations, such as with Navigo Proteins for radiotherapy agents, further bolster OPM’s value proposition, in our view. Upcoming catalysts include the initiation of the REVERT trial for OPM-101 and potential partnering opportunities for OPM-201.

Jyoti Prakash

Written by

Jyoti Prakash, CFA

Director, healthcare

Healthcare

QuickView

11 July 2025

Price €0.38
Market cap €7m
Price Performance
Share details
Code ALOPM
Listing NXT PA

Shares in issue

18.2m

Cash position at 31 December 2024 (excluding €5m raised in April 2025)

€5.1m

Business description

Oncodesign Precision Medicine is a biopharmaceutical company specialised in precision medicine for the treatment of resistant and metastatic cancers.

Bull points

  • Innovative pipeline of first-in-class assets targeting significant unmet needs.
  • Proprietary platforms enable targeted drug discovery and development.
  • Strategic collaborations with industry players enhance development capabilities and validate OPM’s approach.

Bear points

  • Programmes are in early clinical phases, with associated development risks and timelines.
  • Ongoing need for capital to support R&D activities, with potential dilution risks.
  • Operating in highly competitive fields with numerous players targeting similar indications.

Analysts

Jyoti Prakash, CFA
+44 (0)20 3077 5700
Arron Aatkar, PhD
+44 (0)20 3077 5700

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Clinical pipeline entering proof of concept

OPM’s pipeline is led by OPM-101, a first-in-class RIPK2 inhibitor developed with the Nanocyclix platform. After positive Phase I safety data in healthy volunteers, OPM-101 is set to enter the REVERT trial in combination with pembrolizumab for patients with advanced melanoma resistant to anti-PD-1 therapies. The trial will assess safety, determine the recommended Phase II dose and evaluate preliminary efficacy in c 45 patients across multiple European sites; it should conclude by end-2027. OPM-201, targeting LRRK2 for PD, has completed a Phase I trial confirming its safety. After reacquiring full rights from Servier in December 2024, OPM plans to advance the programme internally while seeking new partnerships.

Proprietary platforms enable targeted innovation

OPM’s innovation is anchored in three proprietary platforms. Nanocyclix designs potent and selective macrocyclic kinase inhibitors, forming the basis for OPM’s small molecule drug discovery. OncoSNIPER utilises AI to identify and validate novel therapeutic targets, enhancing the precision of drug development. PROMETHE develops radiolabeled biological molecules for systemic radiotherapy. A strategic collaboration with Navigo Proteins leverages this platform to develop radiotherapy agents targeting resistant and metastatic cancers. These platforms collectively aim to address unmet medical needs through precision medicine.

Funded through near-term clinical milestones

OPM had a cash position of €5.1m at end-2024. In April 2025, it secured equity financing of up to €5m to provide additional financial support for its ongoing activities, particularly the REVERT trial for OPM-101. Based on historical burn rates, and with cost reduction measures in place, this cash position could provide a runway to mid-2026, subject to operational expenditures and financing activities.

Source: LSEG Data & Analytics

Historical financials

Year end Revenue (€m) PBT (€m) EPS (€) DPS (€) P/E (x) Yield (%)
12/23 1.1 (9.9) (0.49) 0.00 N/A N/A
12/24 0.2 (7.8) (0.40) 0.00 N/A N/A

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