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Dosing update at ASH

Sunesis Pharmaceuticals 9 November 2018 Update

Sunesis Pharmaceuticals

Dosing update at ASH

Earnings and clinical update

Pharma & biotech

9 November 2018

Price

US$1.35

Market cap

US$51m

Net cash ($m) at Q318

12.8

Shares in issue

37.4m

Free float

96%

Code

SNSS

Primary exchange

NASDAQ

Secondary exchange

N/A

Share price performance

%

1m

3m

12m

Abs

(38.9)

(42.3)

(49.6)

Rel (local)

(37.2)

(41.3)

(53.4)

52-week high/low

US$7.4

US$1.3

Business description

Sunesis Pharmaceuticals is a pharmaceutical company focused on oncology. Its lead asset is SNS-062, a Bruton’s tyrosine kinase inhibitor for chronic lymphocytic leukemia for Imbruvica-refractory patients. The program is entering a dose escalation Phase Ib/II. It has also developed TAK-580 with partner Takeda, and the preclinical PDK1 inhibitor SNS-510.

Next events

ASH update

1–4 December 2018

SNS-510 IND filing

2019

Analysts

Nathaniel Calloway

+1 646 653 7036

Maxim Jacobs

+1 646 653 7027

Sunesis Pharmaceuticals is a research client of Edison Investment Research Limited

Sunesis released its abstracts for the upcoming American Society of Hematology (ASH) meeting, which included an update on the company’s ongoing Phase Ib/II trial of vecabrutinib in hematologic cancers. The study is still in the dosing portion of the trial on the 50mg arm, but the data to date showed a safety and tolerability profile in line with expectations. The company will provide a complete update of the trial progress at ASH.

Year end

Revenue ($m)

PBT*
($m)

EPS*
($)

DPS
($)

P/E
(x)

Yield
(%)

12/16

2.5

(38.0)

(2.42)

0.00

N/A

N/A

12/17

0.7

(35.5)

(1.45)

0.00

N/A

N/A

12/18e

0.2

(28.8)

(0.81)

0.00

N/A

N/A

12/19e

0.0

(34.9)

(0.94)

0.00

N/A

N/A

Note: *PBT and EPS are normalised, excluding amortisation of acquired intangibles, exceptional items and share-based payments.

The 50mg arm is continuing to enrol

Vecabrutinib is in the dosing portion of a dose escalation/expansion study in patients with chronic lymphocytic leukemia and other hematologic malignancies. The study hit a delay earlier this year when it encountered a dose-limiting toxicity (DLT) that triggered an expansion of the 50mg cohort. In the abstract, the company revealed that some of these patients progressed before completion of their first course, necessitating further enrolment. The 50mg dose is below the threshold of clinical activity, so it is simply an unfortunate risk they have encountered.

AE mostly hematologic; prior DLT due to ALT

The initial safety profile from the evaluation patients was predominantly hematologic, which is to be expected given the patient population and drug class. Additionally there were night sweats, back pain, pyrexia and elevated aminotransferase (ALT). The abstract also revealed that the previously reported DLT was caused by an ALT elevation that prevented complete dosing; although we need further data to fully assess this, it is less of a worry than many alternatives.

Increased evidence on BTK C481 mutations

One of the goals of vecabrutinib is to address the known mechanism of resistance to Imbruvica via mutation of cysteine 481 (C481) of Bruton’s tyrosine kinase (BTK). However, real-world data on the prevalence of this mutation has been sparse. Sunesis participated in a collaborative study being presented at ASH in which patients were examined after three years of Imbruvica treatment, of which 57% had mutations at C481, most of which subsequently progressed. This provides increasing evidence this mechanism is central to Imbruvica resistance.

Valuation: $224m or $5.99 per basic share

Our valuation is negligibly changed at $224.0m (from $224.4m) although it is lower on a per basic-share basis ($5.99 from $6.21) due to an increase in shares outstanding. We have slightly delayed the commercialization of vecabrutinib by six months to 2023, although the impact of this is offset by advancing our NPVs.

ASH abstracts out

On 1 November 2018, Sunesis announced three abstracts it would be presenting at the annual meeting of the ASH on 1–4 December.

Preliminary safety, pharmacokinetic and pharmacodynamic results from a Phase Ib/II dose-escalation and cohort-expansion study of the noncovalent, reversible BTK inhibitor (BTKi), vecabrutinib, in B-lymphoid malignancies

High prevalence of BTK mutations on ibrutinib therapy after three years of treatment in a real-life cohort of chronic lymphocytic leukemia (CLL) patients: a study from the French innovative leukemia organization group

Vecabrutinib is efficacious in vivo in a preclinical CLL adoptive transfer model

We expect to provide more thorough analysis of the data following the presentations, although we can provide some initial insights from the published abstracts.

Phase Ib/II continues to enrol 50mg, no safety surprises

The most immediately important news from the abstracts was the update on the ongoing Phase Ib/II study of vecabrutinib in patients with CLL and other hematologic malignancies. The study is in the dose-ranging phase and the abstract provided the information that enrolment was continuing with the second (50mg twice daily) dosing cohort. Three of the six patients enrolled in the cohort had disease progression before completion of their first treatment cycle, and therefore additional patients will need to be enrolled to complete the cohort. The 50mg dose is below the expected range in which we would expect to see clinical activity, so we do not consider these progressions indicative of issues with the drug, simply an unavoidable risk intrinsic to the study protocol.

The abstract provided an update of the observed adverse events (AEs) to date, which were in line with expectations. Most of the treatment emergent AEs in the study were hematologic (anemia, leukopenia, etc), which can be caused by either these disease or the treatment effect of the drug (although it is too early to draw conclusions in this regard). Night sweats, back pain, pyrexia and elevated ALT were also reported. The company previously expanded the 50mg cohort (per the 3+3 dose escalation protocol) following a DLT, which this abstract revealed was because a patient failed to receive an adequate number of doses in the first cycle due to elevated ALT. We consider the revelation that the DLT was caused by elevated ALT to be preferable to the alternatives. It is still too early to conclude if hepatotoxicity is tied to administration of the drug, but even if it is, it is an AE that can generally be managed. This is a better case than the other events that could be imagined, but continued safety data will be needed to draw any lasting conclusions.

More evidence of the importance of BTK C481

One of the uncertainties regarding vecabrutinib has been a precise understanding of Imbruvica resistance. A mechanism of Imbruvica resistance has been the mutation of C481 in the drug’s target, BTK. Vecabrutinib is a non-covalent inhibitor of BTK and can efficiently bind and inhibit BTK C481 mutants, positioning it as an effective treatment in these patients. However, there has been limited data gathered regarding the frequency of C481 mutations in this population to date. To hopefully illuminate this, Sunesis participated in a study along with a number of French academic institutions to determine the prevalence of various resistance mutations, the data from which will be presented at ASH.

The study examined blood samples from 57 individuals with CLL that had been on Imbruvica treatment for at least three years. Of these, 30 were evaluable for mutations, of which 17 (57%) had C481 mutations (a majority of which were to serine, C418S). A minority (four of 30) had mutation in PLCγ2, which is another known resistance mechanism for Imbruvica. In total, 12 patients on the study progressed within six months of blood-sample collection, 11 of which harboured BTK C481 mutations (and two of which had PLCγ2 mutations). These data are encouraging because it provides additional evidence that C481 is the primary resistance mechanism for Imbruvica.

Vecabrutinib alters T-cell populations in mice

The third presentation that Sunesis will have at ASH regards a preclinical mouse model study in which the impact of vecabrutinib on T-cells is studied. It was found that the drug significantly altered the composition of T-cell subpopulations without changing the ratio of CD4 (helper) to CD8 (killer cells). There was a decrease in regulatory CD4 T-cells, which should result in more immune activation, but this was balanced by a shift in CD8 cells toward naïve cells from memory and effector cells, so the net impact on immune activation is unclear. Other studies have reported similar shifts in T-cell populations in patients on Imbruvica.1 However, the current study also included survival data from mice showing a significant increase in survival (35 days vs 28 days p<0.001), confirming the drug’s activity in this model. We will need further data to fully appreciate what impact, if any, these results indicate.

Podhorecka M, et al. (2017) Changes in T-cell subpopulations and cytokine network during early period of ibrutinib therapy in chronic lymphocytic leukemia patients: the significant decrease in T regulatory cells number. Oncotarget 23, 34661-34669.

Valuation

Our valuation is negligibly changed at $224.0m (from $224.4m) although is lower on a per basic-share basis ($5.99 from $6.21) due to an increase in shares outstanding. We have delayed the expected commercialization of vecabrutinib by approximately six months to account for the increased time to complete the dosing study, which has moved our initial launch date into 2023 (from 2022). However, the impact of this adjustment is offset by advancing our NPVs. We may update our valuation of vecabrutinib in the future following more data from the ongoing study at ASH.

Exhibit 1: Valuation of Sunesis

Development program

Clinical stage

Expected commercialization

Prob. of success

Launch year

Launch Pricing ($)

Peak sales ($m)

Patent/exclusivity protection

Royalty/ margin

rNPV ($m)

TAK-580

Phase I/II

Licensed to Takeda

10%

2025

500,000

603

2032

15%

$19

Vecabrutinib

Phase Ib/II

Proprietary

20%

2023

152,000

666

2034

56%

$187

SNS-510

IND ready

Proprietary

10%

2024

130,000

361

2031

51%

$25

Unallocated costs (discovery programs, administrative costs, etc.)

($20)

Total

 

 

 

 

 

 

 

 

$211

Net cash and equivalents (Q318) ($m)

$12.8

Total firm value ($m)

$224.0

Total basic shares (m)

37.4

Value per basic share ($)

$5.99

Convertible pref stock (m)

6.3

Warrants and options

8.7

Total diluted shares

52.4

Value per diluted share

$4.98

Source: Sunesis reports, Edison Investment Research

Financials

Losses for Q318 were lower than expected at $6.3m due to the continued enrolment into the dosing portion of the vecabrutinib clinical study. We expect R&D expenses to increase when the study enrols a wider number of patients, which we now predict in 2019. This has reduced our expected R&D spending for 2018 to $15.1m from $18.0m. Our financing schedule remains unchanged, however. We expect the company to require at least $135m in additional financing before profitability in 2023, which we record as illustrative debt ($25m, $20m, $30m, $40m and $20m in 2018–2022 respectively).

Exhibit 2: Financial summary

$'000s

2016

2017

2018e

2019e

Year end 31 December

US GAAP

US GAAP

US GAAP

US GAAP

PROFIT & LOSS

Revenue

 

 

2,536

669

237

0

Cost of Sales

0

0

0

0

Gross Profit

2,536

669

237

0

Research and development

(22,881)

(21,540)

(15,123)

(17,485)

Selling, general & administrative

(16,115)

(13,548)

(12,575)

(12,952)

EBITDA

 

 

(36,313)

(34,428)

(27,470)

(30,447)

Operating Profit (before GW and except.)

(36,302)

(34,419)

(27,461)

(30,438)

Intangible Amortisation

0

0

0

0

Exceptionals/Other

0

0

0

0

Operating Profit

(36,302)

(34,419)

(27,461)

(30,438)

Net Interest

(1,721)

(1,039)

(1,360)

(4,475)

Other (change in fair value of warrants)

0

0

0

0

Profit Before Tax (norm)

 

 

(38,023)

(35,458)

(28,821)

(34,912)

Profit Before Tax (IFRS)

 

 

(38,023)

(35,458)

(28,821)

(34,912)

Tax

0

0

0

0

Deferred tax

0

0

0

0

Profit After Tax (norm)

(38,023)

(35,458)

(28,821)

(34,912)

Profit After Tax (IFRS)

(38,023)

(35,458)

(28,821)

(34,912)

Average Number of Shares Outstanding (m)

15.7

24.5

35.6

37.2

EPS - normalised ($)

 

 

(2.42)

(1.45)

(0.81)

(0.94)

EPS - IFRS ($)

 

 

(2.42)

(1.45)

(0.81)

(0.94)

Dividend per share ($)

0.0

0.0

0.0

0.0

BALANCE SHEET

Fixed Assets

 

 

3

1,401

11

2

Intangible Assets

0

0

0

0

Tangible Assets

3

20

11

2

Other

0

1,381

0

0

Current Assets

 

 

43,231

32,933

38,989

28,318

Stocks

0

0

0

0

Debtors

0

0

0

0

Cash

42,588

31,750

37,687

27,016

Other

643

1,183

1,302

1,302

Current Liabilities

 

 

(5,814)

(8,901)

(1,414)

(1,554)

Creditors

(2,481)

(1,697)

(1,414)

(1,554)

Short term borrowings

(3,333)

(7,204)

0

0

Long Term Liabilities

 

 

(11,271)

(112)

(32,400)

(52,400)

Long term borrowings

(11,102)

0

(32,396)

(52,396)

Other long term liabilities

(169)

(112)

(4)

(4)

Net Assets

 

 

26,149

25,321

5,186

(25,634)

CASH FLOW

Operating Cash Flow

 

 

(36,962)

(36,142)

(25,373)

(30,671)

Net Interest

0

0

0

0

Tax

0

0

0

0

Capex

0

(26)

0

0

Acquisitions/disposals

0

0

0

0

Financing

26,111

32,930

6,303

0

Dividends

0

0

0

0

Other

0

0

0

0

Net Cash Flow

(10,851)

(3,238)

(19,070)

(30,671)

Opening net debt/(cash)

 

 

(38,596)

(28,153)

(24,546)

(5,291)

HP finance leases initiated

0

0

0

0

Exchange rate movements

0

0

0

0

Other

408

(369)

(185)

0

Closing net debt/(cash)

 

 

(28,153)

(24,546)

(5,291)

25,380

Source: Sunesis reports, Edison Investment Research

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world-renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisers and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

DISCLAIMER
Copyright 2018 Edison Investment Research Limited. All rights reserved. This report has been commissioned by Sunesis Pharmaceuticals and prepared and issued by Edison for publication globally. All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report. Opinions contained in this report represent those of the research department of Edison at the time of publication. The securities described in the Investment Research may not be eligible for sale in all jurisdictions or to certain categories of investors. This research is issued in Australia by Edison Investment Research Pty Ltd (Corporate Authorised Representative (1252501) of Myonlineadvisers Pty Ltd (AFSL: 427484)) and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. The Investment Research is distributed in the United States by Edison US to major US institutional investors only. Edison US is registered as an investment adviser with the Securities and Exchange Commission. Edison US relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. As such, Edison does not offer or provide personalised advice. We publish information about companies in which we believe our readers may be interested and this information reflects our sincere opinions. The information that we provide or that is derived from our website is not intended to be, and should not be construed in any manner whatsoever as, personalised advice. Also, our website and the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. This document is provided for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.
Edison has a restrictive policy relating to personal dealing. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report. Edison or its affiliates may perform services or solicit business from any of the companies mentioned in this report. The value of securities mentioned in this report can fall as well as rise and are subject to large and sudden swings. In addition it may be difficult or not possible to buy, sell or obtain accurate information about the value of securities mentioned in this report. Past performance is not necessarily a guide to future performance. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (ie without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision. To the maximum extent permitted by law, Edison, its affiliates and contractors, and their respective directors, officers and employees will not be liable for any loss or damage arising as a result of reliance being placed on any of the information contained in this report and do not guarantee the returns on investments in the products discussed in this publication. FTSE International Limited (“FTSE”) © FTSE 2018. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

295 Madison Avenue, 18th Floor

10017, New York

US

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

295 Madison Avenue, 18th Floor

10017, New York

US

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world-renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisers and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

DISCLAIMER
Copyright 2018 Edison Investment Research Limited. All rights reserved. This report has been commissioned by Sunesis Pharmaceuticals and prepared and issued by Edison for publication globally. All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report. Opinions contained in this report represent those of the research department of Edison at the time of publication. The securities described in the Investment Research may not be eligible for sale in all jurisdictions or to certain categories of investors. This research is issued in Australia by Edison Investment Research Pty Ltd (Corporate Authorised Representative (1252501) of Myonlineadvisers Pty Ltd (AFSL: 427484)) and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. The Investment Research is distributed in the United States by Edison US to major US institutional investors only. Edison US is registered as an investment adviser with the Securities and Exchange Commission. Edison US relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. As such, Edison does not offer or provide personalised advice. We publish information about companies in which we believe our readers may be interested and this information reflects our sincere opinions. The information that we provide or that is derived from our website is not intended to be, and should not be construed in any manner whatsoever as, personalised advice. Also, our website and the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. This document is provided for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.
Edison has a restrictive policy relating to personal dealing. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report. Edison or its affiliates may perform services or solicit business from any of the companies mentioned in this report. The value of securities mentioned in this report can fall as well as rise and are subject to large and sudden swings. In addition it may be difficult or not possible to buy, sell or obtain accurate information about the value of securities mentioned in this report. Past performance is not necessarily a guide to future performance. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (ie without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision. To the maximum extent permitted by law, Edison, its affiliates and contractors, and their respective directors, officers and employees will not be liable for any loss or damage arising as a result of reliance being placed on any of the information contained in this report and do not guarantee the returns on investments in the products discussed in this publication. FTSE International Limited (“FTSE”) © FTSE 2018. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

295 Madison Avenue, 18th Floor

10017, New York

US

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

295 Madison Avenue, 18th Floor

10017, New York

US

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

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