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Last close As at 25/01/2023
▲ −0.82 (−11.08%)
Cantargia is a clinical-stage biotechnology company based in Sweden. It is developing two assets against IL1RAP, CAN04 and CAN10. CAN04 is being studied in several solid tumours with a main focus on NSCLC and pancreatic cancer. The most advanced trial is in Phase II.
Increasing understanding of inflammation in malignant processes now includes findings that cytokines are not only produced by the immune cells, but that cancer itself can produce certain cytokines and the associated receptors to escape from the immune response. Therefore, cytokines represent a potentially promising class of targets in oncology.
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Cantargia is developing antibodies against IL1RAP. Data from its Phase IIa CANFOUR trial, investigating nadunolimab in first-line non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC), support the hypothesis that nadunolimab has a synergistic benefit with chemotherapy. At the ASCO Annual Meeting in June, Cantargia presented promising interim results for nadunolimab from a Phase I/IIa in PDAC and a Phase IIa trial in NSCLC.
The company is now preparing for the Phase II/III trial in metastatic PDAC in collaboration with PanCAN. A second programme, CAN10, is being developed for treatment of myocarditis and systemic sclerosis. New supportive preclinical data were recently presented and Phase I clinical trials are planned for early 2023. Nadunolimab is being investigated across eight different cancers in different combinations. Cantargia had a cash and short-term investment position of SEK496.5m at end-Q322.
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