Associated equity: Oryzon Genomics
Spanish biotech Oryzon Genomics is focused on epigenetics. Iadademstat is being explored for haematology-oncology, where the strategic priority is in first-line acute myeloid leukaemia; there is potential for an accelerated approval pathway should clinical data continue to be supportive. It is also being evaluated in other indications, such as myelodysplastic syndrome, myeloproliferative neoplasms and sickle cell disease, as well as in small cell lung cancer. Central nervous system asset vafidemstat has completed a Phase IIb trial in borderline personality disorder and preparations are underway for Phase III. It is also currently involved in a Phase IIb trial for schizophrenia, and management is preparing for an additional Phase II trial in autism spectrum disorder.
Oryzon Genomics — 8 videos in collection
Spanish biotech Oryzon Genomics is among the leading clinical-stage drug developers, with a second generation of epigenetic therapeutics that have greater selectivity and a potentially favourable safety/efficacy profile compared with the first-generation HDAC inhibitors. Oryzon is focused on epigenetics in oncology and the central nervous system (CNS). Iadademstat is being explored for acute leukaemias, small-cell lung cancer (SCLC) and neuroendocrine tumours. CNS asset vafidemstat has completed several Phase IIa trials and a Phase IIb trial in borderline personality disorder is now the lead study.
In this interview, Oryzon CEO Carlos Buesa recaps the company’s pipeline and provides a preview of the upcoming rich newsflow.