Business update and Q316 results

Transgene 28 October 2016 Update

Transgene

Business update and Q316 results

Q316 results update

Pharma & biotech

28 October 2016

Price

€2.68

Market cap

€103m

Net cash and ST investments (€m) at 30 September 2016

25.4

Shares in issue

38.5m

Free float

43%

Code

TNG

Primary exchange

Euronext Paris

Secondary exchange

N/A

Share price performance

%

1m

3m

12m

Abs

(1.2)

2.1

(2.6)

Rel (local)

(3.5)

0.2

3.0

52-week high/low

€3.80

€2.35

Business description

Transgene is a French drug discovery and development company focused on the treatment of cancer and infectious diseases with immunotherapies. The lead products are Pexa-Vec (in Phase III for HCC) and TG4010 (Phase IIb complete for NSCLC).

Next events

TG4010 +Opdivo NSCLC (second-line) trial start

H216

Pexa-Vec +Yervoy Solid Tumours
trial start

H216

Analysts

Juan Pedro Serrate

+44 (0)20 3681 2534

Daniel Wilkinson

+44 (0)20 3077 5734

Transgene is a research client of Edison Investment Research Limited

During Q316 Transgene announced a collaboration agreement with Pfizer and Merck to develop TG4001 in combination with avelumab in a Phase I/II trial, the recruitment of the first patient in the multiple-dose cohort of Phase I/Ib of TG4001 in HBV patients and preclinical data from its vaccinia technology platform. The company plans to raise €48.1m (gross) through a rights issue that will fund operations to the end of 2018. Cash and equivalents at end Q316 amount to €25.4m. We value Transgene at €161.5m or €4.2/share.

Year
end

Revenue (€m)

PBT*
(€m)

EPS*
(€)

DPS
(€)

P/E
(x)

Yield
(%)

12/14

11.1

(38.9)

(1.03)

0.0

N/A

N/A

12/15

9.6

(28.9)

(0.78)

0.0

N/A

N/A

12/16e

6.1

(27.2)

(0.71)

0.0

N/A

N/A

12/17e

7.8

(31.5)

(0.82)

0.0

N/A

N/A

Note: *PBT and EPS are normalised, excluding amortisation of acquired intangibles, exceptional items and share-based payments.

Rights issue to fund strategy into first readouts

Transgene announced a rights issue for a planned gross amount of €48.1m. The subscription period will end on 4 November. The company will use funds to continue with its strategy of combining key pipeline assets with immune checkpoint inhibitors. In total, seven clinical trials are due to start before end 2017, with the first readouts expected in H217. With cash and equivalents of €25.4m at end Q316, the company guides FY16 cash burn at €35m.

Deal with Pfizer and Merck on combination trial

Transgene has entered into a collaboration with Pfizer and Merck KGaA to evaluate TG4001 in combination with immune checkpoint inhibitor (ICI) avelumab for second-line human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC). The study is slated to start in H117; Pfizer and Merck will provide avelumab and will co-design the Phase I/II clinical trial with Transgene. The company will cover most expenses. Additional details were not disclosed.

Additional newsflow

During the quarter, Transgene announced the inclusion of the first patient in the multiple-dose cohort of the Phase I/Ib study of TG1050 (HBV vaccine). This trial evaluates the safety, tolerability and antiviral activity of TG1050 in patients with chronic Hepatitis B infection who are being treated with standard-of-care antiviral therapy. The first data readout is expected in H217. Additionally, preclinical data from its vaccinia technology platform were presented at the 10th International Meeting on Replicating Oncolytic Virus in Vancouver, Canada.

Valuation: Updating NPV to €161.5m or €4.2/share

We are updating the cash position to €25.4m, but introduce no further changes to our DCF valuation, which moves to €4.2/share (from €4.40/share). We await the results of the rights issue before updating our model.

Rights issue and deal execution reinforces strategy

The company’s strategy involves developing its pipeline assets in combination with other products, predominantly immune checkpoint inhibitors (ICIs). The combination of ICIs with other products, especially other immunotherapeutics, is becoming increasingly popular in the oncology space, as demonstrated by the number of this type of study. At August 2016 there were 734 ongoing combination trials with 47 ICIs, according to Beacon Intelligence. In particular, there is increasing interest from the industry to combine ICIs with cancer vaccines or oncolytic viruses. As an example, Bavarian Nordic’s prostate cancer vaccine ProstVac is undergoing a Phase II trial in combination with Bristol-Myers Squibb’s ipilimumab. Oncolytic virus therapy Imlygic (talimogene laherparepvec, Amgen) is being tested in combination with ipilimumab in a Phase II trial in advanced melanoma.

To fund operations for the next two years, Transgene announced a subscription rights issue to existing shareholders. As a result of the capital increase, approximately 18.5m new shares will be issued at €2.60/share, raising c €48.1m gross. Institut Mérieux, Transgene’s key shareholder, has committed to subscribing up to 75% of the total number of the new shares. The subscription period to exercise rights and subscribe for new shares starts on 27 October and ends on 4 November 2016.

Exhibit 1: Transgene Clinical pipeline

Compound

Combination Compound

Indication

Phase

Collaborators

Trial start date

Data Readout

TG4010

Opdivo (Nivolumab) (BMY) anti-PD-1

Second-line NSCLC

II

UC Davis Medical Centre (US)

H216

2017

TG4010

Unspecified ICI

First-line NSCLC

II

N/A

H117

N/A

TG4010

N/A

Neoadjuvant NSCLC

Translational

N/A

2017

N/A

Pexa-Vec

Sorafenib

First-line HCC

III

Conducted by partner SillaJen

Ongoing

2019

Pexa-Vec

Yervoy (Ipilimumab) (BMY) anti CTLA-4

Solid Tumours

II

Centre Leon Berard

H216

2017

Pexa-Vec

Opdivo (Nivolumab) (BMY) anti-PD-1

First-line HCC

II

N/A

H117

N/A

TG4001

Avelumab (Pfizer/Merck) anti-PD-L1

HPV positive head and neck cancer

II

Prof Christopher Le Tourneau, Institut Curie, principal investigator

H117

N/A

TG1050

Standard of care antiviral

Chronic hepatitis B

I/Ib

N/A

Ongoing

H217

TG6002

N/A

Glioblastoma

I

Assistance Publique Hôpitaux, Paris (PI Pr Delattre), support from French National Cancer Institute

H117

N/A

Source: Edison Research Investment, Transgene

Collaboration agreement with Pfizer and Merck

Transgene has announced a collaboration agreement with Pfizer and Merck to combine TG4001 and avelumab, a fully human monoclonal antibody that inhibits programmed cell death ligand 1 (PD-L1) in a Phase I/II study in second-line HPV-positive HNSCC. The trial will be funded by Transgene and will start in H117. Pfizer and Merck will provide avelumab and co-design the Phase I and II cohorts of the study, which will be open label and enrol up to 50 patients; endpoints will include response rate and duration of response. Further details on the trial design, financial terms, IP rights or other aspects of the agreement have not been disclosed.

TG4001 is a therapeutic vaccine based on a modified vaccinia virus Ankara (MVA) vector engineered to express HPV 16 antigens E6 and E7 with adjuvant interleukin-2 (IL-2). Clinical data from 206 female patients with CIN2/3 Intraepithelial Cervical Neoplasia showed a 38% (20/52) clearance rate in HPV 16 mono-infected patients compared with 9% for placebo (2/23) (p value = 0.009) with a favourable safety profile.

According to ClinicalTrials.gov, avelumab is being tested in 19 clinical trials, eight of which are in combination with other products in various oncology indications. In particular, avelumab is expected to start a small Phase I trial in patients with locally advanced HNSCC in combination with radiotherapy and cetuximab in Q416. Two multi-tumour Phase I trials include cohorts with HNSCC patients and are currently recruiting patients. An additional Phase II trial is recruiting patients with nasopharyngeal cancer, a form of HNSCC. There are no data available from these studies and first readouts could occur in mid-2018, according to ClinicalTrials.gov timelines.

Data from a pivotal Phase II study published in Lancet Oncology in second-line metastatic Merkel cell carcinoma (MCC) showed an overall response rate of 31.8% (n=88, irrespective of PD-L1 status), with Grade 1 or 2 treatment-related adverse events (AEs) in 62 patients (70.5%). Grade 3 treatment-related AEs were reported in four patients (5%). There were no Grade 4 treatment-related AEs or deaths. Merck plans to apply for approval in MCC in the US and Europe by end 2016.

Head and neck cancer is a heterogeneous group of cancers in the oral cavity, oropharynx, larynx, nasal cavity and salivary glands that affect 500,000 people annually worldwide. Over 90% of cases are squamous cell carcinomas (HNSCC). Annual incidences of oropharyngeal squamous cell cancers have risen to 6.2 per 100,000 men and 1.4 per 100,000 women in the US and 73% of these tumours are HPV positive (data from 2004-08 period). The current treatments are surgery, chemotherapy and/or radiation, aggressive and with significant toxicities.

Additional newsflow

During the quarter Transgene announced that the first patient had been dosed in the multiple dose cohort of an ongoing Phase I/Ib trial of TG1050 with standard of care in HBV patients. TG1050 is a therapeutic vaccine for the treatment of chronic Hepatitis B that expresses three antigens of the Hepatitis B virus. This announcement comes after the Safety Review Committee recommended its continuation. The Phase I/Ib trial is an international, randomised, double-blind, placebo-controlled safety and dose-finding study evaluating single and multiple doses of TG1050 in patients who are currently being treated for chronic HBV infection with standard-of-care antiviral therapy (n=48). Secondary objectives include the antiviral activity of and immune responses to TG1050. Data are expected in H217. There are currently limited treatments for HBV. The cure rate from nucleotide analogues such as tenofovir (Viread) and entecavir (Baraclude) or pegylated interferon-α is only 3-5%, so that patients normally need long-term antiviral therapy to control their infection. Around 240 million people have chronic HBV infection, according to the World Health Organization (WHO). Transgene will look to partner TG1050 once it has proof-of-concept data from this study.

Furthermore, preclinical work was presented at the 10th International Meeting on Replicating Oncolytic Virus Therapeutics held in Vancouver, Canada on 1-4 October 2016. The company presented a new technique to improve the cytotoxic power of vaccinia vectors based on intracellular fragments that overcome cancer cell resistance. This work underscores Transgene’s vaccinia platform capabilities for the design of the next generation of preclinical candidates. These data build on previously published experiments in April 2016 at the American Association for Cancer Research (AACR) meeting in New Orleans. At AACR, Transgene reported data from several oncolytic virus constructs, which showed they could express anti-PD-1 fragments and accumulate in tumours, with a similar anti-tumour effect as a combination of anti-PD-1 antibody and oncolytic virus and better than any of the single products in a preclinical model.

Financials and valuation: Cash updated, NPV of €161.5m

We are updating our valuation, with reported cash of €25.4m at end September 2016, which results in an NPV of €161.5m or €4.2/share (from €169.5m or €4.40/share). We will update our valuation with the new shares and total cash raised once the subscription period for the rights issue closes on 4 November. We are currently not introducing any changes to our assumptions until we receive more information on the clinical data for both the ongoing trials and the upcoming combination studies.

Transgene reported that operating revenue for the first nine months of 2016 (9M16) was down to €6.4m from €7.5m in the same period in 2015 (9M15), which was mainly due to a reduction in the eligible research and development expenses that decreased from €6.4m in 9M15 to €4.4m in 9M16. Cash and cash equivalents, including available-for-sale financial assets, stood at €25.4m as of 30 September 2016 (€31.7m as of 31 December 2015). Cash does not include the recently announced share capital increase, by which the company aims to raise a gross €48.1m.

Cash burn for the first nine months of 2016 was €16.3m (excluding the EIB loan), approximately half of which was burnt in Q3 (€8.1m). Removing €4.2m net cash outflows linked to the restructuring plan, cash burn stood at €12.1m for the first nine months of 2016. Transgene expects to burn €35m by year end as it ramps up its clinical programme. In Q416 a reduction in tax credits received and milestone payments paid, in addition to the clinical programme, will contribute to this increased burn.


Exhibit 2: Financial summary

€'000s

2013

2014

2015

2016e

2017e

Year end 31 December

IFRS

IFRS

IFRS

IFRS

IFRS

PROFIT & LOSS

Revenue

 

 

15,735

11,099

9,565

6,086

7,835

Cost of Sales

0

0

0

0

0

Gross Profit

15,735

11,099

9,565

6,086

7,835

R&D expenses

(50,063)

(41,731)

(32,138)

(27,465)

(32,958)

G&A expenses

(6,769)

(7,578)

(5,798)

(4,339)

(4,469)

EBITDA

 

 

(38,287)

(35,453)

(25,671)

(23,943)

(27,858)

Operating Profit (before GW and except)

 

(40,813)

(38,127)

(27,957)

(25,584)

(29,488)

Intangible Amortisation

(385)

(365)

(350)

(135)

(105)

Exceptionals (restructuring costs / discontinued operations)

0

(8,440)

(15,965)

0

0

Operating Profit

(41,198)

(46,932)

(44,272)

(25,719)

(29,592)

Other

0

0

0

0

0

Net Interest

(730)

(801)

(930)

(1,579)

(2,034)

Profit Before Tax (norm)

 

 

(41,543)

(38,928)

(28,887)

(27,163)

(31,522)

Profit Before Tax (IFRS)

 

 

(41,928)

(47,733)

(45,202)

(27,298)

(31,627)

Tax

0

0

0

0

0

Minority interest

(930)

(823)

(1,172)

0

0

Profit After Tax (norm)

(42,473)

(39,751)

(30,059)

(27,163)

(31,522)

Profit After Tax (IFRS)

(42,858)

(48,556)

(46,374)

(27,298)

(31,627)

Average Number of Shares Outstanding (m)

31.9

38.5

38.5

38.5

38.5

EPS - normalised (c)

 

 

(1.33)

(103.25)

(78.08)

(70.55)

(81.87)

EPS - IFRS (c)

 

 

(1.34)

(126.12)

(120.45)

(70.90)

(82.15)

Dividend per share (c)

0.0

0.0

0.0

0.0

0.0

BALANCE SHEET

Fixed Assets

 

 

64,501

61,715

49,841

49,440

49,135

Intangible Assets

1,329

1,056

485

350

245

Tangible Assets

23,988

23,641

16,559

16,293

16,093

Other

39,184

37,018

32,797

32,797

32,797

Current Assets

 

 

61,349

79,238

51,028

42,772

28,237

Stocks

975

1,149

1,164

1,164

1,164

Debtors

1,896

1,540

1,784

1,784

429

Cash

47,862

65,935

31,650

26,894

13,713

Other

10,616

10,614

16,430

12,930

12,930

Current Liabilities

 

 

(23,996)

(21,563)

(26,725)

(19,697)

(20,796)

Creditors

(9,364)

(8,296)

(6,521)

(5,493)

(6,592)

Short term borrowings

0

0

0

0

0

Short term leases

(8,830)

(8,992)

(9,396)

(9,396)

(9,396)

Other

(5,802)

(4,275)

(10,808)

(4,808)

(4,808)

Long Term Liabilities

 

 

(45,232)

(47,551)

(47,597)

(66,953)

(76,316)

Long term borrowings

0

0

0

(20,000)

(30,000)

Long term leases

(40,788)

(43,199)

(44,401)

(43,757)

(43,120)

Other long term liabilities

(4,444)

(4,352)

(3,196)

(3,196)

(3,196)

Net Assets

 

 

56,622

71,839

26,547

5,561

(19,740)

CASH FLOW

Operating Cash Flow

 

 

(50,186)

(55,037)

(46,082)

(30,495)

(24,915)

Net Interest

244

801

930

(1,579)

(2,034)

Tax

0

0

0

0

0

Capex

(2,184)

(2,602)

(1,527)

(1,374)

(1,429)

Acquisitions/disposals

0

0

0

3,500

0

Financing

70

62,735

477

0

0

Dividends

0

0

0

0

0

Other

7,902

12,527

12,975

5,836

5,836

Net Cash Flow

(44,154)

18,424

(33,227)

(24,113)

(22,542)

Opening net debt/(cash)

 

 

(53,948)

1,756

(13,744)

22,147

46,260

HP finance leases initiated

(11,411)

(3,191)

(2,646)

0

0

Other

(139)

267

(18)

(0)

0

Closing net debt/(cash)

 

 

1,756

(13,744)

22,147

46,260

68,802

Source: Transgene, Edison Investment Research

Edison, the investment intelligence firm, is the future of investor interaction with corporates. Our team of over 100 analysts and investment professionals work with leading companies, fund managers and investment banks worldwide to support their capital markets activity. We provide services to more than 400 retained corporate and investor clients from our offices in London, New York, Frankfurt, Sydney and Wellington. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison and is not regulated by the Australian Securities and Investment Commission. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

DISCLAIMER
Copyright 2016 Edison Investment Research Limited. All rights reserved. This report has been commissioned by Transgene and prepared and issued by Edison for publication globally. All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report. Opinions contained in this report represent those of the research department of Edison at the time of publication. The securities described in the Investment Research may not be eligible for sale in all jurisdictions or to certain categories of investors. This research is issued in Australia by Edison Aus and any access to it, is intended only for "wholesale clients" within the meaning of the Australian Corporations Act. The Investment Research is distributed in the United States by Edison US to major US institutional investors only. Edison US is registered as an investment adviser with the Securities and Exchange Commission. Edison US relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. As such, Edison does not offer or provide personalised advice. We publish information about companies in which we believe our readers may be interested and this information reflects our sincere opinions. The information that we provide or that is derived from our website is not intended to be, and should not be construed in any manner whatsoever as, personalised advice. Also, our website and the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. This document is provided for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.
Edison has a restrictive policy relating to personal dealing. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report. Edison or its affiliates may perform services or solicit business from any of the companies mentioned in this report. The value of securities mentioned in this report can fall as well as rise and are subject to large and sudden swings. In addition it may be difficult or not possible to buy, sell or obtain accurate information about the value of securities mentioned in this report. Past performance is not necessarily a guide to future performance. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (ie without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision. To the maximum extent permitted by law, Edison, its affiliates and contractors, and their respective directors, officers and employees will not be liable for any loss or damage arising as a result of reliance being placed on any of the information contained in this report and do not guarantee the returns on investments in the products discussed in this publication. FTSE International Limited (“FTSE”) © FTSE 2016. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

245 Park Avenue, 39th Floor

10167, New York

US

Sydney +61 (0)2 9258 1161

Level 25, Aurora Place

88 Phillip St, Sydney

NSW 2000, Australia

Wellington +64 (0)48 948 555

Level 15, 171 Featherston St

Wellington 6011

New Zealand

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

245 Park Avenue, 39th Floor

10167, New York

US

Sydney +61 (0)2 9258 1161

Level 25, Aurora Place

88 Phillip St, Sydney

NSW 2000, Australia

Wellington +64 (0)48 948 555

Level 15, 171 Featherston St

Wellington 6011

New Zealand

Edison, the investment intelligence firm, is the future of investor interaction with corporates. Our team of over 100 analysts and investment professionals work with leading companies, fund managers and investment banks worldwide to support their capital markets activity. We provide services to more than 400 retained corporate and investor clients from our offices in London, New York, Frankfurt, Sydney and Wellington. Edison is authorised and regulated by the Financial Conduct Authority. Edison Investment Research (NZ) Limited (Edison NZ) is the New Zealand subsidiary of Edison. Edison NZ is registered on the New Zealand Financial Service Providers Register (FSP number 247505) and is registered to provide wholesale and/or generic financial adviser services only. Edison Investment Research Inc (Edison US) is the US subsidiary of Edison and is regulated by the Securities and Exchange Commission. Edison Investment Research Limited (Edison Aus) [46085869] is the Australian subsidiary of Edison and is not regulated by the Australian Securities and Investment Commission. Edison Germany is a branch entity of Edison Investment Research Limited [4794244]. www.edisongroup.com

DISCLAIMER
Copyright 2016 Edison Investment Research Limited. All rights reserved. This report has been commissioned by Transgene and prepared and issued by Edison for publication globally. All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report. Opinions contained in this report represent those of the research department of Edison at the time of publication. The securities described in the Investment Research may not be eligible for sale in all jurisdictions or to certain categories of investors. This research is issued in Australia by Edison Aus and any access to it, is intended only for "wholesale clients" within the meaning of the Australian Corporations Act. The Investment Research is distributed in the United States by Edison US to major US institutional investors only. Edison US is registered as an investment adviser with the Securities and Exchange Commission. Edison US relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. As such, Edison does not offer or provide personalised advice. We publish information about companies in which we believe our readers may be interested and this information reflects our sincere opinions. The information that we provide or that is derived from our website is not intended to be, and should not be construed in any manner whatsoever as, personalised advice. Also, our website and the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. This document is provided for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.
Edison has a restrictive policy relating to personal dealing. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report. Edison or its affiliates may perform services or solicit business from any of the companies mentioned in this report. The value of securities mentioned in this report can fall as well as rise and are subject to large and sudden swings. In addition it may be difficult or not possible to buy, sell or obtain accurate information about the value of securities mentioned in this report. Past performance is not necessarily a guide to future performance. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (ie without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision. To the maximum extent permitted by law, Edison, its affiliates and contractors, and their respective directors, officers and employees will not be liable for any loss or damage arising as a result of reliance being placed on any of the information contained in this report and do not guarantee the returns on investments in the products discussed in this publication. FTSE International Limited (“FTSE”) © FTSE 2016. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

245 Park Avenue, 39th Floor

10167, New York

US

Sydney +61 (0)2 9258 1161

Level 25, Aurora Place

88 Phillip St, Sydney

NSW 2000, Australia

Wellington +64 (0)48 948 555

Level 15, 171 Featherston St

Wellington 6011

New Zealand

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

245 Park Avenue, 39th Floor

10167, New York

US

Sydney +61 (0)2 9258 1161

Level 25, Aurora Place

88 Phillip St, Sydney

NSW 2000, Australia

Wellington +64 (0)48 948 555

Level 15, 171 Featherston St

Wellington 6011

New Zealand

Share this with friends and colleagues